De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives

Heim, C; Pliatsika, D; Mousavizadeh, F; Bar, K; Alvarez, BH; Giannis, A; Hartman, MD

Hartman, MD (reprint author), Max Planck Inst Dev Biol, Dept Prot Evolut, Max Planck Ring 5, D-72076 Tubingen, Germany.; Giannis, A (reprint author), Univ Leipzig, Fac Chem & Mineral, Inst Organ Chem, Johannisallee 29, D-04103 Leipzig, Germany.

JOURNAL OF MEDICINAL CHEMISTRY, 2019; 62 (14): 6615

Abstract

Targeted protein degradation via cereblon (CRBN), a substrate receptor of an E3 ubiquitin ligase complex, is an increasingly important strategy in var......

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