In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase CIpC1

Gopal, P; Tasneen, R; Yee, M; Lanoix, JP; Sarathy, J; Rasic, G; Li, LP; Dartois, V; Nuermberger, E; Dick, T

Dick, T (reprint author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Microbiol & Immunol, Singapore, Singapore.; Dick, T (reprint author), Natl Univ Singapore, 5 Sci Dr 2, Singapore 117545, Singapore.

ACS INFECTIOUS DISEASES, 2017; 3 (7): 492

Abstract

Through mutant selection on agar containing pyrazinoic acid (POA), the bioactive form of the prodrug pyrazinamide (PZA), we recently showed that misse......

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