Virtual screening, SAR, and discovery of 5-(indole-3-yl)-2-[(2-nitrophenyl)amino] [1,3,4]-oxadiazole as a novel Bcl-2 inhibitor

Ziedan, NI; Hamdy, R; Cavaliere, A; Kourti, M; Prencipe, F; Brancale, A; Jones, AT; Westwell, AD

Ziedan, NI (reprint author), Cardiff Univ, Sch Pharm & Pharmaceut Sci, Cardiff, S Glam, Wales.

CHEMICAL BIOLOGY & DRUG DESIGN, 2017; 90 (1): 147

Abstract

A new series of oxadiazoles were designed to act as inhibitors of the anti-apoptotic Bcl-2 protein. Virtual screening led to the discovery of new hits......

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