Structure Modeling of Human Tyrosyl-DNA Phosphodiesterase 1 and Screening for Its Inhibitors

Gushchina, IV; Nilov, DK; Zakharenko, AL; Lavrik, OI; Svedas, VK

Svedas, VK (reprint author), Lomonosov Moscow State Univ, Fac Bioengn & Bioinformat, Lenin Hills 1,Bldg 73, Moscow 119991, Russia.; Svedas, VK (reprint author), Lomonosov Moscow State Univ, Belozersky Inst Physicochem Biol, Lenin Hills 1,Bldg 40, Moscow 1

ACTA NATURAE, 2017; 9 (2): 59

Abstract

The DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) represents a potential molecular target for anticancer therapy. A human Tdp1 model has be......

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