Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface

Heo, Y; Ishimoto, N; Jeon, YE; Yun, JH; Ohki, M; Anraku, Y; Sasaki, M; Kita, S; Fukuhara, H; Ikuta, T; Kawakami, K; Inoue, A; Maenaka, K; Tame, JRH; Lee, W; Park, SY

Lee, W (通讯作者)，Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biochem, Struct Biochem & Mol Biophys Lab, Seoul, South Korea.;Park, SY (通讯作者)，Yokohama City Univ, Grad Sch Med Life Sci, Drug Design Lab, Yokohama, Japan.;Lee, W (通讯作者)，PCG Biotech Ltd, Seoul, South Korea.

PLOS BIOLOGY, 2022; 20 (8):

Abstract

Galanin is a neuropeptide expressed in the central and peripheral nervous systems, where it regulates various processes including neuroendocrine relea......

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