A seven-residue deletion in PrP leads to generation of a spontaneous prion formed from C-terminal C1 fragment of PrP

Munoz-Montesino, C; Larkem, D; Barbereau, C; Igel-Egalon, A; Truchet, S; Jacquet, E; Nhiri, N; Moudjou, M; Sizun, C; Rezaei, H; Beringue, V; Dron, M

Dron, M (corresponding author), Univ Versailles St Quentin En Yvelines, Univ Paris Saclay, Inst Natl Rech Agr Alimentat & Environm, Virol & Immunol Mol, Jouy En Josas, France.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2020; 295 (41): 14025

Abstract

Prions result from a drastic conformational change of the host-encoded cellular prion protein (PrP), leading to the formation of beta-sheet-rich, inso......

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