Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity

Kim, MJ; Biag, J; Fass, DM; Lewis, MC; Zhang, Q; Fleishman, M; Gangwar, SP; Machius, M; Fromer, M; Purcell, SM; McCarroll, SA; Rudenko, G; Premont, RT; Scolnick, EM; Haggarty, SJ

Haggarty, SJ (reprint author), Massachusetts Gen Hosp, Dept Neurol, Chem Neurobiol Lab, Boston, MA 02114 USA.; Haggarty, SJ (reprint author), Massachusetts Gen Hosp, Dept Psychiat, Chem Neurobiol Lab, Boston, MA 02114 USA.

MOLECULAR PSYCHIATRY, 2017; 22 (3): 417

Abstract

Although the pathogenesis of schizophrenia (SCZ) is proposed to involve alterations of neural circuits via synaptic dysfunction, the underlying molecu......

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