Characterising covalent warhead reactivity

Martin, JS; MacKenzie, CJ; Fletcher, D; Gilbert, IH

Gilbert, IH (reprint author), Univ Dundee, Div Biol Chem & Drug Discovery, Wellcome Ctr Antiinfect Res, Drug Discovery Unit, Dundee DD1 5EH, Scotland.

BIOORGANIC & MEDICINAL CHEMISTRY, 2019; 27 (10): 2066

Abstract

Many drugs currently used are covalent inhibitors and irreversibly inhibit their targets. Most of these were discovered through serendipity. Covalent ......

Full Text Link