Recent developments of human monocarboxylate transporter (hMCT) inhibitors as anticancer agents

Wu, PH; Zhou, Y; Guo, YZ; Zhang, SL; Tam, KY

Tam, KY (corresponding author), Univ Macau, Fac Hlth Sci, Canc Ctr, Macau, Peoples R China.; Zhang, SL (corresponding author), Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, 55 Daxuecheng South Rd, Chongqing 401331, Peoples R China.

DRUG DISCOVERY TODAY, 2021; 26 (3): 836

Abstract

Cancer cells metabolize glucose via anaerobic glycolysis, with lactate formed in the cytosol as the end-product. To avoid intercellular acidification,......

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