A DddA ortholog-based and transactivator-assisted nuclear and mitochondrial cytosine base editors with expanded target compatibility

Guo, JF; Yu, WX; Li, M; Chen, HY; Liu, J; Xue, XW; Lin, JX; Huang, SS; Shu, WJ; Huang, XX; Liu, Z; Wang, SQ; Qiao, YB

Qiao, YB (通讯作者)，Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Shanghai 200125, Peoples R China.;Qiao, YB (通讯作者)，Shanghai Inst Precis Med, Shanghai 200125, Peoples R China.;Liu, Z (通讯作者)，Chinese Acad, CAS Ctr Excellence Brain Sci & Intelligence Techno, CAS Key Lab Primate Neurobiol, State Key Lab Neurosci,Sci Inst Neurosci, Shanghai 200031, Peoples R China.;Wang, SQ (通讯作者)，Acad Mil Med Sci, Bioinformat Ctr, Beijing 100850, Peoples R China.

MOLECULAR CELL, 2023; 83 (10): 1710

Abstract

Bacterial double-stranded DNA (dsDNA) cytosine deaminase DddAtox-derived cytosine base editor (DdCBE) and its evolved variant, DddA11, guided by trans......

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