Macrophage HIF-2 alpha regulates tumor-suppressive Spint1 in the tumor microenvironment

Susen, RM; Bauer, R; Olesch, C; Fuhrmann, DC; Fink, AF; Dehne, N; Jain, A; Ebersberger, I; Schmid, T; Brune, B

Brune, B (reprint author), Goethe Univ Frankfurt, Fac Med, Inst Biochem 1, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.

MOLECULAR CARCINOGENESIS, 2019; 58 (11): 2127

Abstract

In solid tumors, tumor-associated macrophages (TAMs) commonly accumulate within hypoxic areas. Adaptations to such environments evoke transcriptional ......

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