Synthesis of PET probe O-6-[(3-[C-11]methyl)benzyl]guanine by Pd-0-mediated rapid C-[C-11]methylation toward imaging DNA repair protein O-6-methylguanine-DNA methyltransferase in glioblastoma

Koyama, H; Ikenuma, H; Toda, H; Kondo, G; Hirano, M; Kato, M; Abe, J; Yamada, T; Wakabayashi, T; Ito, K; Natsume, A; Suzuki, M

Koyama, H (reprint author), Gifu Univ, Grad Sch Med, Div Regenerat & Adv Med Sci, 1-1 Yanagido, Gifu 5011194, Japan.; Suzuki, M (reprint author), Natl Ctr Geriatr & Gerontol, Ctr Dev Adv Med Dementia, Dept Clin & Expt Neuroimaging, 7-430 Morioka Cho, Obu,

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017; 27 (9): 1892

Abstract

O-6-Benzylguanine (O-6-BG) is a substrate of O-6-methylguanine-DNA methyltransferase (MGMT), which is involved in drug resistance of chemotherapy in t......

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