Development of a Robust and Scalable Process for the Large-Scale Preparation of Vadadustat

Lin, BY; Kou, JP; Wu, SM; Cai, XR; Xiao, QB; Li, YL; Hu, J; Li, JB; Wang, ZQ

Wang, ZQ (corresponding author), HEC Pharm Grp, Dept Proc Res & Dev, Dongguan 523871, Peoples R China.; Wang, ZQ (corresponding author), Sunshine Lake Pharma Co Ltd, State Key Lab Antiinfect Drug Dev 2015DQ780357, Dongguan 523871, Peoples R China.; Wang, ZQ (corresponding author), Xiangnan Univ, Sch Pharm, Chenzhou 423000, Hunan, Peoples R China.

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021; 25 (4): 960

Abstract

A novel and scalable process is developed for the industrial synthesis of vadadustat. The four-step process is one step shorter compared to the report......

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