WGCNA-Based DNA Methylation Profiling Analysis on Allopurinol-Induced Severe Cutaneous Adverse Reactions: A DNA Methylation Signature for Predisposing Drug Hypersensitivity

Cheng, L; Sun, B; Xiong, Y; Hu, L; Gao, LC; Li, J; Xie, HF; Chen, XP; Zhang, W; Zhou, HH

Cheng, L (通讯作者)，Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Peoples R China.;Cheng, L (通讯作者)，Wenzhou Med Univ, Eye Hosp, Sch Ophthalmol & Optometry, Wenzhou 325027, Peoples R China.;Zhou, HH (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Peoples R China.;Zhou, HH (通讯作者)，Cent South Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Peoples R China.

JOURNAL OF PERSONALIZED MEDICINE, 2022; 12 (4):

Abstract

Background: The role of aberrant DNA methylation in allopurinol-induced severe cutaneous adverse reactions (SCARs) is incompletely understood. To fill......

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