Autoreactive CD8(+) T-cells are highly dependent on CD8 for activation and as such targeting CD8 is an effective way of blocking autoreactive CD8(+) T-cell activation

Wooldridge, L; Morgan, D; Pearson, JA; Gras, S; van den Berg, H; Lissina, A; Llewellyn-Lacey, S; Willis, M; Dockree, T; McLaren, JE; Ekeruche-Makinde, J; Gostick, E; Robertson, N; Rossjohn, J; Burrows, SR; Price, D; Wong, S; Peakman, M; Skowera, A; C

JOURNAL OF IMMUNOLOGY, 2017; 198 (1):