Stereoselective Synthesis of Anti-Hepatitis B Drug, Entecavir, through Regio- and Stereoselective Epoxide Cleavage

Hyun, YE; Kim, HR; Choi, Y; Jeong, LS

Jeong, LS (reprint author), Seoul Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Seoul 08826, South Korea.; Choi, Y (reprint author), Korea Univ, Coll Life Sci & Biotechnol, Seoul 024820, South Korea.

ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2017; 6 (9): 1213

Abstract

A stereoselective synthesis of entecavir, an anti-hepatitis B (HBV) drug, was accomplished by a regioselective isopropylidene cleavage, stereoselectiv......

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