Amino acids and RagD potentiate mTORC1 activation in CD8(+) T cells to confer antitumor immunity

Zhang, YW; Hu, HR; Liu, WW; Yan, SM; Li, YZ; Tan, LK; Chen, YS; Liu, J; Peng, ZL; Yuan, YC; Huang, WJ; Yu, F; He, X; Li, B; Zhang, H

Zhang, H (corresponding author), Sun Yat Sen Univ, Inst Human Virol, Zhongshan Sch Med,Key Lab Trop Dis Control,Minist, Guangdong Engn Res Ctr Antimicrobial Agent & Immu, Guangzhou, Guangdong, Peoples R China.; Li, B (corresponding author), Sun Yat Sen Univ, Zhongshan Sch Med, Dept Biochem, Guangzhou, Guangdong, Peoples R China.

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (4):

Abstract

Background In the tumor microenvironment, tumor cells are able to suppress antitumor immunity by competing for essential nutrients, including amino ac......

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