Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC)

Zhang, ZM; Connolly, PJ; Lim, HK; Pande, V; Meerpoel, L; Teleha, C; Branch, JR; Ondrus, J; Hickson, I; Bush, T; Luistro, L; Packman, K; Bischoff, JR; Ibrahim, S; Parrett, C; Chong, Y; Gottardis, MM; Bignan, G

Zhang, ZM; Bignan, G (corresponding author), Janssen Res & Dev, Spring House, PA 19477 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2021; 64 (2): 909

Abstract

Persistent androgen receptor (AR) activation drives therapeutic resistance to second-generation AR pathway inhibitors and contributes to the progressi......

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