Soluble guanylate cyclase stimulator praliciguat attenuates inflammation, fibrosis, and end-organ damage in the Dahl model of cardiorenal failure

Shea, CM; Price, GM; Liu, G; Sarno, R; Buys, ES; Currie, MG; Masferrer, JL

Buys, ES (corresponding author), Cyclerion Therapeut, 301 Binney St, Cambridge, MA 02142 USA.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2020; 318 (1): F148

Abstract

Reduced nitric oxide (NO) and a decrease in cGMP signaling mediated by soluble guanylate cyclase (sGC) has been linked to the development of several c......

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