SMAC Mimetic/IAP Inhibitor Birinapant Enhances Radiosensitivity of Glioblastoma Multiforme

Cerna, D; Lim, B; Adelabu, Y; Yoo, S; Carter, D; Fahim, A; Mitsuuchi, Y; Teicher, BA; Bernhard, E; Coleman, CN; Takebe, N; Ahmed, MM

Takebe, N (corresponding author), NCI, Div Canc Treatment & Diag, 31 Ctr Dr,Suite 3A44, Bethesda, MD 20892 USA.; Ahmed, MM (corresponding author), NCI, NIH, Mol Radiat Therapeut, Radiat Res Program,Div Canc Treatment & Diag, 9609 Med Ctr Dr,Room 3W224, Rockville, MD 20850 USA.

RADIATION RESEARCH, 2021; 195 (6): 549

Abstract

Birinapant is a novel SMAC peptidomimetic molecule in clinical development. It suppresses the inhibitor of apoptosis proteins (IAPs) and promotes cyto......

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