The duplication mutation of Quebec platelet disorder dysregulates PLAU, but not C10orf55, selectively increasing production of normal PLAU transcripts by megakaryocytes but not granulocytes

Hayward, CPM; Liang, MG; Tasneem, S; Soomro, A; Waye, JS; Paterson, AD; Rivard, GE; Wilson, MD

Hayward, CPM (reprint author), McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada.; Hayward, CPM (reprint author), McMaster Univ, Dept Med, Hamilton, ON, Canada.; Hayward, CPM (reprint author), Hamilton Reg Lab Med Program, Hamilton, ON, Canada.;

PLOS ONE, 2017; 12 (3):

Abstract

Quebec Platelet disorder (QPD) is a unique bleeding disorder that markedly increases urokinase plasminogen activator (uPA) in megakaryocytes and plate......

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