Stabilization of protein-protein interactions in drug discovery

Andrei, SA; Sijbesma, E; Hann, M; Davis, J; O'Mahony, G; Perry, MWD; Karawajczyk, A; Eickhoff, J; Brunsveld, L; Doveston, RG; Milroy, LG; Ottmann, C

Ottmann, C (reprint author), Eindhoven Univ Technol, Lab Chem Biol, Dept Biomed Engn, Eindhoven, Netherlands.; Ottmann, C (reprint author), Eindhoven Univ Technol, Inst Complex Mol Syst, Eindhoven, Netherlands.; Ottmann, C (reprint author), Univ Duisburg

EXPERT OPINION ON DRUG DISCOVERY, 2017; 12 (9): 925

Abstract

Introduction: PPIs are involved in every disease and specific modulation of these PPIs with small molecules would significantly improve our prospects ......

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