Parent and Metabolite Concentration-QT Modeling to Evaluate QT-Interval Prolongation at Savolitinib Therapeutic Doses

Schalkwijk, S; Sahota, T; Verheijen, RB; Harmer, AR; Ahmed, GF

Schalkwijk, S (corresponding author), AstraZeneca, BioPharmaceut R&D, Clin Pharmacol & Safety Sci, Cambridge, England.

AAPS JOURNAL, 2021; 23 (3):

Abstract

Savolitinib is an oral, potent, and highly selective MET-tyrosine kinase inhibitor under investigation in various tumor types. A thorough QT study eva......

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