Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death

Margreiter, MA; Witzenberger, M; Wasser, Y; Davydova, E; Janowski, R; Metz, J; Habib, P; Sahnoun, SEM; Sobisch, C; Poma, B; Palomino-Hernandez, O; Wagner, M; Carell, T; Shah, NJ; Schulz, JB; Niessing, D; Voigt, A; Rossetti, G

Rossetti, G (通讯作者),Forschungszentrum Juelich, Inst Neurosci & Med INM 9, Julich, Germany.;Niessing, D (通讯作者),Helmholtz Zentrum Muenchen, Inst Struct Biol, German Res Ctr Environm Hlth, D-85764 Neuherberg, Germany.;Schulz, JB; Voigt, A; Rossetti, G (通讯作者),Rhein Westfal TH Aachen, RWTH Aachen Univ, Fac Med, Dept Neurol, Pauwelsstr 30, D-52074 Aachen, Germany.;Schulz, JB; Voigt, A (通讯作者),JARA Brain Translat Med, Aachen, Germany.;Schulz, JB (通讯作者),Forschungszentrum Juelich, Inst Neurosci & Med INM 1

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2022; 20 (): 443

Abstract

Polyglutamine (polyQ) diseases are characterized by an expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats encoding for an uninterrupted......

Full Text Link