Restriction of AID activity and somatic hypermutation by PARP-1

Tepper, S; Mortusewicz, O; Czlonka, E; Bello, A; Schmidt, A; Jeschke, J; Fischbach, A; Pfeil, I; Petersen-Mahrt, SK; Mangerich, A; Helleday, T; Leonhardt, H; Jungnickel, B

Jungnickel, B (reprint author), Friedrich Schiller Univ, Inst Biochem & Biophys, Sch Biol & Pharm, Dept Cell Biol, D-07745 Jena, Germany.; Jungnickel, B (reprint author), Univ Konstanz, Dept Biol, D-78457 Constance, Germany.

NUCLEIC ACIDS RESEARCH, 2019; 47 (14): 7418

Abstract

Affinity maturation of the humoral immune response depends on somatic hypermutation (SHM) of immunoglobulin (Ig) genes, which is initiated by targeted......

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