Importance of target-mediated drug disposition for small molecules

Smith, DA; van Waterschoot, RAB; Parrott, NJ; Olivares-Morales, A; Lave, T; Rowland, M

van Waterschoot, RAB (reprint author), Roche Innovat Ctr Basel, Roche Pharmaceut Res & Early Dev, Pharmaceut Sci, Basel, Switzerland.

DRUG DISCOVERY TODAY, 2018; 23 (12): 2023

Abstract

Target concentration is typically not considered in drug discovery. However, if targets are expressed at relatively high concentrations and compounds ......

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