Modeling Approach to Predict the Impact of Inflammation on the Pharmacokinetics of CYP2C19 and CYP3A4 Substrates

Simon, F; Gautier-Veyret, E; Truffot, A; Chenel, M; Payen, L; Stanke-Labesque, F; Tod, M

Simon, F (corresponding author), Univ Lyon 1, Fac Med Lyon Sud, EA3738, F-69921 Oullins, France.

PHARMACEUTICAL RESEARCH, ; ():

Abstract

Purpose For decades, inflammation has been considered a cause of pharmacokinetic variability, mainly in relation to the inhibitory effect of pro-infla......

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