Discovery of a class of highly potent Janus Kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling

Zak, M; Hanan, EJ; Lupardus, P; Brown, DG; Robinson, C; Siu, M; Lyssikatos, JP; Romero, FA; Zhao, GL; Kellar, T; Mendonca, R; Ray, NC; Goodacre, SC; Crackett, PH; McLean, N; Hurley, CA; Yuen, PW; Cheng, YX; Liu, XC; Liimatta, M; Kohli, PB; Nonomiya,

Zak, M (reprint author), Genentech Inc, 1 DNA Way, San Francisco, CA 94080 USA.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019; 29 (12): 1522

Abstract

Disruption of interleukin-13 (IL-13) signaling with large molecule antibody therapies has shown promise in diseases of allergic inflammation. Given th......

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