Metabolic origin of the fused aminoacyl-tRNA synthetase, glutamyl-prolyl-tRNA synthetase

Eswarappa, SM; Potdar, AA; Sahoo, S; Sankar, S; Fox, PL

Eswarappa, SM (reprint author), Indian Inst Sci, Dept Biochem, Bengaluru 560012, India.; Fox, PL (reprint author), Cleveland Clin, Lerner Res Inst, Dept Cellular & Mol Med, Cleveland, OH 44195 USA.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2018; 293 (49): 19148

Abstract

About 1 billion years ago, in a single-celled holozoan ancestor of all animals, a gene fusion of two tRNA synthetases formed the bifunctional enzyme, ......

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