Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors

Chino, A; Seo, R; Amano, Y; Namatame, I; Hamaguchi, W; Honbou, K; Mihara, T; Yamazaki, M; Tomishima, M; Masuda, N

Chino, A (reprint author), Astellas Pharma Inc, Drug Discovery Res, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan.

CHEMICAL & PHARMACEUTICAL BULLETIN, 2018; 66 (3): 286

Abstract

In this study, we report the identification of potent pyrimidoindazoles as phosphodiesterase10A (PDE10A) inhibitors by using the method of fragment-ba......

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