Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma

Gao, YX; Xu, QG; Li, XQ; Guo, Y; Zhang, BW; Jin, Y; Zhu, CL; Shen, YT; Yang, PX; Shi, Y; Jin, RF; Liu, DJ; Ouyang, YB; Liu, XN; Wang, WJ; Chen, DX; Yang, TW

Yang, TW (通讯作者)，Capital Med Univ, Beijing Inst Hepatol, Beijing 100069, Peoples R China.;Yang, TW (通讯作者)，Qingdao Univ, Affiliated Hosp, Organ Transplantat Ctr, Qingdao 266003, Peoples R China.

CELL DEATH & DISEASE, 2022; 13 (3):

Abstract

Tumor heterogeneity has been associated with immunotherapy and targeted drug resistance in hepatocellular carcinoma (HCC). However, communications bet......

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