Osmolytes Can Destabilize Proteins in Cells by Modulating Electrostatics and Quinary Interactions

Song, XF; An, LY; Wang, MT; Chen, JF; Liu, ZJ; Yao, LS

Yao, LS (corresponding author), Chinese Acad Sci, Key Lab Biofuels, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China.; Yao, LS (corresponding author), Chinese Acad Sci, Shandong Prov Key Lab Synthet Biol, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Peoples R China.

ACS CHEMICAL BIOLOGY, 2021; 16 (5): 864

Abstract

Although numerous in vitro studies have shown that osmolytes are capable of stabilizing proteins, their effect on protein folding in vivo has been les......

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