Inhibition of UGT1A1*1 and UGT1A1*6 catalyzed glucuronidation of SN-38 by silybins

Li, W; Chen, YN; Chen, YY; Wang, Z; Wang, Z; Jiang, LL; Shi, HC; Liu, Y

Shi, HC (通讯作者)，Yangzhou Univ, Translat Med Res Inst, Coll Med, Yangzhou 225001, Peoples R China.;Liu, Y (通讯作者)，Dalian Univ Technol, Sch Life & Pharmaceut Sci, Panjin 124221, Peoples R China.

CHEMICO-BIOLOGICAL INTERACTIONS, 2022; 368 ():

Abstract

UGT1A1 is the main enzyme that catalyzes the metabolic elimination and detoxification of SN-38, the active form of the drug irinotecan. Milk thistle p......

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