Highly Potent 17 beta-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy

Siebenbuerger, L; Hernandez-Olmos, V; Abdelsamie, AS; Frotscher, M; van Koppen, CJ; Marchais-Oberwinkler, S; Scheuer, C; Laschke, MW; Menger, MD; Boerger, C; Hartmann, RW

Hartmann, RW (reprint author), Saarland Univ, Dept Pharm, Campus C2-3, D-66123 Saarbrucken, Germany.; Hartmann, RW (reprint author), Helmholtz Inst Pharmaceut Res Saarland HIPS, Dept Drug Design & Optimizat, Campus E8-1, D-66123 Saarbrucken, Germany.

JOURNAL OF MEDICINAL CHEMISTRY, 2018; 61 (23): 10724

Abstract

Intracellular elevation of E2 levels in bone by inhibition of 17 beta hydroxysteroid dehydrogenase type 2 (17 beta-HSD2) without affecting systemic E2......

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