Repurposing fluphenazine to suppress melanoma brain, lung and bone metastasis by inducing G0/G1 cell cycle arrest and apoptosis and disrupting autophagic flux

Xi, HZ; Wu, ML; Ma, HB; Li, SR; Huang, QR; Zhang, YW; Xia, Y

Zhang, YW; Xia, Y (通讯作者)，Sichuan Univ, West China Hosp, Collaborat Innovat Ctr Biotherapy, Dept Rehabil Med, Chengdu 610041, Peoples R China.;Zhang, YW; Xia, Y (通讯作者)，Sichuan Univ, West China Hosp, Canc Ctr, Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China.;Xia, Y (通讯作者)，Rehabil Med Res Inst, Key Lab Rehabil Med Sichuan Prov, Chengdu 610041, Peoples R China.

CLINICAL & EXPERIMENTAL METASTASIS, 2023; 40 (2): 161

Abstract

Brain metastasis is the main cause of treatment failure and melanoma-related death. Inadequate concentrations of therapeutic drugs in the brain due to......

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