Rgs16 promotes antitumor CD8(+) T cell exhaustion

Weisshaar, N; Wu, JX; Ming, YA; Madi, A; Hotz-Wagenblatt, A; Ma, SC; Mieg, A; Hering, M; Zettl, F; Mohr, K; Schlimbach, T; Ten Bosch, N; Hertel, F; Muller, L; Byren, H; Wang, M; Borgers, H; Munz, M; Schmitt, L; van der Hoeven, F; Kloz, U; Carretero, R; Schleussner, N; Jackstadt, RF; Hofmann, I; Cui, GL

Cui, GL (通讯作者)，German Canc Res Ctr, T Cell Metab Grp D192, Neuenheimer Feld 280, D-69120 Heidelberg, Germany.;Cui, GL (通讯作者)，Heidelberg Univ, Fac Biosci, D-69120 Heidelberg, Germany.;Cui, GL (通讯作者)，Helmholtz Inst Translat Oncol HI TRON, D-55131 Mainz, Germany.

SCIENCE IMMUNOLOGY, 2022; 7 (71):

Abstract

T cells become functionally exhausted in tumors, limiting T cell-based immunotherapies. Although several transcription factors regulating the exhauste......

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