Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus

Nystrom, K; Wanrooij, PH; Waldenstrom, J; Adamek, L; Brunet, S; Said, J; Nilsson, S; Wind-Rotolo, M; Hellstrand, K; Norder, H; Tang, KW; Lagging, M

Lagging, M (reprint author), Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Infect Dis Virol, Gothenburg, Sweden.

JOURNAL OF VIROLOGY, 2018; 92 (19):

Abstract

A third of humans carry genetic variants of the ITP pyrophosphatase (ITPase) gene (ITPA) that lead to reduced enzyme activity. Reduced ITPase activity......

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