Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFR(WT)and EGFR(T790M)

Nasser, AA; Eissa, IH; Oun, MR; El-Zahabi, MA; Taghour, MS; Belal, A; Saleh, AM; Mehany, ABM; Luesch, H; Mostafa, AE; Afifi, WM; Rocca, JR; Mahdy, HA

Eissa, IH; El-Zahabi, MA; Mahdy, HA (corresponding author), Al Azhar Univ, Fac Pharm Boys, Pharmaceut Med Chem & Drug Design Dept, Cairo 11889, Egypt.

ORGANIC & BIOMOLECULAR CHEMISTRY, 2020; 18 (38): 7608

Abstract

A new series of pyrimidine-5-carbonitrile derivatives has been designed as ATP mimicking tyrosine kinase inhibitors of the epidermal growth factor rec......

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