BACH2 immunodeficiency illustrates an association between super-enhancers and haploinsufficiency

Afzali, B; Gronholm, J; Vandrovcova, J; O'Brien, C; Sun, HW; Vanderleyden, I; Davis, FP; Khoder, A; Zhang, Y; Hegazy, AN; Villarino, AV; Palmer, IW; Kaufman, J; Watts, NR; Kazemian, M; Kamenyeva, O; Keith, J; Sayed, A; Kasperaviciute, D; Mueller, M;

Afzali, B (reprint author), NIAMSD, Lymphocyte Cell Biol Sect, Mol Immunol & Inflammat Branch, Biodata Min & Discovery Sect,NIH, Bethesda, MD 20892 USA.; Afzali, B (reprint author), NIAMSD, Prot Express Lab, NIH, Bethesda, MD 20892 USA.; Afzali, B (reprin

NATURE IMMUNOLOGY, 2017; 18 (7): 813

Abstract

The transcriptional programs that guide lymphocyte differentiation depend on the precise expression and timing of transcription factors (TFs). The TF ......

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