The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells

Dixit, D; Prager, BC; Gimple, RC; Poh, HX; Wang, Y; Wu, QL; Qiu, ZX; Kidwell, RL; Kim, LJY; Xie, Q; Vitting-Seerup, K; Bhargava, S; Dong, Z; Jiang, L; Zhu, Z; Hamerlik, P; Jaffrey, SR; Zhao, JC; Wang, XX; Rich, JN

Wang, XX (corresponding author), Univ Calif San Diego, Dept Med, Div Regenerat Med, San Diego, CA 92103 USA.; Zhao, JC (corresponding author), Sanford Burnham Prebys Med Discovery Inst, Tumor Initiat & Maintenance Program, La Jolla, CA 92037 USA.; Wang, XX (corresponding author), Nanjing Med Univ, Sch Basic Med Sci, Nanjing, Peoples R China.; Rich, JN (corresponding author), Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA.

CANCER DISCOVERY, 2021; 11 (2): 480

Abstract

Glioblastoma is a universally lethal cancer driven by glioblastoma stem cells (GSC). Here, we interrogated N-6-methyladenosine (m6A) mRNA modification......

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