Structure-Activity Relationship of SPOP Inhibitors against Kidney Cancer

Dong, Z; Wang, Z; Guo, ZQ; Gong, SZ; Zhang, T; Liu, J; Luo, C; Jiang, HL; Yang, CG

Yang, CG (corresponding author), Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China.; Yang, CG (corresponding author), Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, UCAS, Hangzhou 310024, Peoples R China.

JOURNAL OF MEDICINAL CHEMISTRY, 2020; 63 (9): 4849

Abstract

Speckle-type POZ protein (SPOP) is overexpressed in the nucleus and misallocated in the cytoplasm in almost all the clear-cell renal cell carcinomas (......

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