Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma

Pandey, GK; Landman, N; Neikes, HK; Hulsman, D; Lieftink, C; Beijersbergen, R; Kolluri, KK; Janes, SM; Vermeulen, M; Badhai, J; van Lohuizen, M

Badhai, J (通讯作者)，Netherlands Canc Inst, Div Mol Genet, Plesmanlaan 121, NL-1066CX Amsterdam, Netherlands.;Badhai, J; van Lohuizen, M (通讯作者)，Oncode Inst, Utrecht, Netherlands.

CELL REPORTS MEDICINE, 2023; 4 (2):

Abstract

More than half of patients with malignant mesothelioma show alterations in the BAP1 tumor-suppressor gene. Being a member of the Polycomb repressive d......

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