Enasidenib induces acute myeloid leukemia cell differentiation to promote clinical response

Amatangelo, MD; Quek, L; Shih, A; Stein, EM; Roshal, M; David, MD; Marteyn, B; Farnoud, NR; de Botton, S; Bernard, OA; Wu, B; Yen, KE; Tallman, MS; Papaemmanuil, E; Penard-Lacronique, V; Thakurta, A; Vyas, P; Levine, RL

Thakurta, A (reprint author), Celgene Corp, Translat Dev, 556 Morris Ave, Summit, NJ 07901 USA.

BLOOD, 2017; 130 (6): 732

Abstract

Recurrent mutations at R140 and R172 in isocitrate dehydrogenase 2 (IDH2) occur in many cancers, including similar to 12% of acute myeloid leukemia (A......

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