Organic Anion Transporter 2 Mediates Hepatic Uptake of Tolbutamide, a CYP2C9 Probe Drug

Bi, YA; Mathialagan, S; Tylaska, L; Fu, M; Keefer, J; Vildhede, A; Costales, C; Rodrigues, AD; Varma, MVS

Varma, MVS (reprint author), Pfizer Inc, Pfizer Global Res & Dev, Pharmacokinet Dynam & Metab, MS 8220-2451, Groton, CT 06340 USA.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2018; 364 (3): 390

Abstract

Tolbutamide is primarily metabolized by CYP2C9, and, thus, is frequently applied as a clinical probe substrate for CYP2C9 activity. However, there is ......

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