A human receptor occupancy assay to measure anti-PD-1 binding in patients with prior anti-PD-1

Junker, F; Gulati, P; Wessels, U; Seeber, S; Stubenrauch, KG; Codarri-Deak, L; Markert, C; Klein, C; Teixeira, PC; Kao, H

Junker, F (corresponding author), F Hoffmann La Roche Ltd, Roche Innovat Ctr Basel, Pharmaceut Sci, Roche Pharma Res & Early Dev, Grenzacherstr 124, CH-4070 Basel, Switzerland.

CYTOMETRY PART A, ; ():

Abstract

Receptor occupancy (RO) assessment by flow cytometry is an important pharmacodynamic (PD) biomarker in the clinical development of large molecules suc......

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