Origins of the RAG Transposome and the MHC

Tsakou-Ngouafo, L; Paganini, J; Kaufman, J; Pontarotti, P

Pontarotti, P (corresponding author), Aix Marseille Univ IRD, APHM, MEPHI, IHU Mediterranee Infect, 19-21 Blvd Jean Moulin, F-13005 Marseille 3, France.; Kaufman, J (corresponding author), Univ Cambridge, Dept Pathol, Tennis Court Rd, Cambridge CB2 1QP, England.; Kaufman, J (corresponding author), Univ Cambridge, Dept Vet Med, Madingley Rd, Cambridge CB2 0ES, England.; Kaufman, J (corresponding author), Univ Edinburgh, Inst Immunol & Infect Res, Charlotte Auerbach Rd, Edinburgh EH9 3FL, Midlothian, Scotland.; Pontarotti, P (corresponding author), SNC5039 CNRS, 19-21 Blvd Jean Moulin, F-13005 Marseilles, France.

TRENDS IN IMMUNOLOGY, 2020; 41 (7): 561

Abstract

How innate immunity gave rise to adaptive immunity in vertebrates remains unknown. We propose an evolutionary scenario beginning with pathogen-associa......

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