Dual threshold optimization and network inference reveal convergent evidence from TF binding locations and TF perturbation responses

Kang, YM; Patel, NR; Shively, C; Recio, PS; Chen, XH; Wranik, BJ; Kim, G; McIsaac, RS; Mitra, R; Brent, MR

Brent, MR (corresponding author), Washington Univ, Sch Med, Ctr Genome Sci & Syst Biol, St Louis, MO 63110 USA.; Brent, MR (corresponding author), Washington Univ, Dept Comp Sci & Engn, St Louis, MO 63130 USA.

GENOME RESEARCH, 2020; 30 (3): 459

Abstract

A high-confidence map of the direct, functional targets of each transcription factor (TF) requires convergent evidence from independent sources. Two s......

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