How Semiphysiological Population Pharmacokinetic Modeling Incorporating Active Hepatic Uptake Supports Phase II Dose Selection of RO7049389, A Novel Anti-Hepatitis B Virus Drug

Cosson, V; Feng, S; Jaminion, F; Lemenuel-Diot, A; Parrott, N; Paehler, A; Bo, QY; Jin, YY

Cosson, V (corresponding author), Roche Innovat Ctr Basel, Pharmaceut Sci, Roche Pharma Res & Amp Early Dev, Basel, Switzerland.

CLINICAL PHARMACOLOGY & THERAPEUTICS, ; ():

Abstract

The pharmacokinetics (PK) of RO7049389, a new hepatitis B virus (HBV) core protein allosteric modulator of class I, and of its active metabolite M5 we......

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