Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation

Patsoukis, N; Duke-Cohan, JS; Chaudhri, A; Aksoylar, HI; Wang, Q; Council, A; Berg, A; Freeman, GJ; Boussiotis, VA

Boussiotis, VA (corresponding author), Beth Israel Deaconess Med Ctr, Div Hematol Oncol, Boston, MA 02215 USA.; Boussiotis, VA (corresponding author), Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA.

COMMUNICATIONS BIOLOGY, 2020; 3 (1):

Abstract

Patsoukis et al identify a mechanism by which SHP-2 phosphatase bridges two molecules of the inhibitory checkpoint receptor PD-1, and show this can al......

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