A novel PLK1 inhibitor onvansertib effectively sensitizes MYC-driven medulloblastoma to radiotherapy

Wang, D; Veo, B; Pierce, A; Fosmire, S; Madhavan, K; Balakrishnan, I; Donson, A; Alimova, I; Sullivan, KD; Joshi, M; Erlander, M; Ridinger, M; Foreman, NK; Venkataraman, S; Vibhakar, R

Vibhakar, R (通讯作者),Univ Colorado Denver, Dept Pediat, Aurora, CO 80045 USA.

NEURO-ONCOLOGY, 2022; 24 (3): 414

Abstract

Background Group 3 medulloblastoma (MB) is often accompanied by MYC amplification. PLK1 is an oncogenic kinase that controls cell cycle and proliferat......

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